An EAACI Task Force report on allergy to beta-lactams in children: Clinical entities and diagnostic procedures

Blanca-Lopez N., Atanaskovic-Markovic M., Gomes E. R., Kidon M., KUYUCU S., Mori F., ...Daha Fazla

PEDIATRIC ALLERGY AND IMMUNOLOGY, cilt.32, sa.7, ss.1426-1436, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 32 Sayı: 7
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/pai.13529
  • Dergi Adı: PEDIATRIC ALLERGY AND IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1426-1436
  • Anahtar Kelimeler: beta-lactam allergy, children, immediate reactions, non-immediate reactions, STEVENS-JOHNSON-SYNDROME, TOXIC EPIDERMAL NECROLYSIS, SICKNESS-LIKE REACTION, NONIMMEDIATE HYPERSENSITIVITY REACTIONS, DRUG-INDUCED ANAPHYLAXIS, SERUM-SICKNESS, SKIN-TESTS, PENICILLIN ALLERGY, FATAL ANAPHYLAXIS, PROVOCATION TEST
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Beta-lactam (BL) allergy suspicion is common in children and constitutes a major public health problem, with an impact on patient's health and on medical costs. However, it has been found that most of these reactions are not confirmed by a complete allergic workup. The diagnostic value of the currently available allergy tests has been investigated intensively recently by different groups throughout the world. This has led to major changes in the management of children with a suspected BL allergy. Particularly, it is now well accepted that skin tests can be skipped before the drug provocation test in children with a benign non-immediate reaction to BL. However, there is still a debate on the optimal allergic workup to perform in children with a benign immediate reaction. In addition, management of children with severe cutaneous adverse drug reactions remains difficult. In this review, based on a selection of the most relevant studies found in the literature, we will review and discuss the diagnosis of different forms of BL allergy in children.