In this study, the main emphasis is placed on the development and characterization of alkali-activated binders completely produced by the use of mixed construction and demolition waste (CDW)-based masonry units as aluminosilicate precursors. Combined usage of precursors was aimed to better simulate the real-life cases since in the incident of construction and demolition, these wastes are anticipated to be generated collectively. As different masonry units, red clay brick (RCB), hollow brick (HB) and roof tile (RT) were used in binary combinations by 75-25%, 50-50% and 25-75% of the total weight of the binder. Mixtures were produced with different curing temperature/periods and molarities of NaOH solution as the alkaline activator. Characterization was made by the compressive strength measurements supported by microstructural investigations which included the analyses of X-ray diffraction (XRD) and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDX). Results clearly showed that completely CDW-based masonry units can be effectively used collectively in producing alkali-activated binders having up to 80 MPa compressive strength provided that the mixture design parameters are optimized. Among different precursors utilized, HB seems to contribute more to the compressive strength. Irrespective of their composition, main reaction products of alkali-activated binders from CDW-based masonry units are sodium aluminosilicate hydrate (N-A-S-H) gels containing different zeolitic polytypes with structure ranging from amorphous to polycrystalline.