During the Mio-Pliocene between ca. 10 and 5 Ma, the Central Anatolian Volcanic Province (CAVP) formed as the focus of a high eruptive flux episode with voluminous high-silica, caldera-forming eruptions. Magmatic compositions of ignimbrites emplaced during this episode were uniformly rhyodadtic-rhyolitic, reflecting melt generation in an intracrustal hot zone heated by intrusions of basalt that were extracted from fertile asthenospheric mantle undergoing decompression. The clear imprint of crustal rocks on CAVP magmas provides unique opportunity to constrain the deep crustal architecture of central Anatolia. Here, we present a detailed study of zircon from key CAVP ignimbrites induding U-Pb ages and the first coupled O- and Hf-isotopic compositions for this silicic igneous province, along with complementary whole-rock Nd isotope data. Ignimbrites with higher delta O-18 and lower cHIvalues (Zelve,Cemilktiy,Gordeles) are typically compositionally more evolved compared to those with intermediate (Kayak, Kizilkaya) and more mantle-like compositions (Sanmadentepe, Sofular, Tahar), which is consistent with magmas acquiring their isotopic compositions through crustal assimilation coupled with fractional crystallization. Intriguingly, 0-Hf-zircon compositions from Kizilkaya ignimbrite, one of the largest and youngest CAVP eruptions, cover almost the same isotopic range than all CAVP ignimbrites collectively. Despite evidence for a significant crustal influence revealed by O-Nd-H1 isotopic compositions of CAVP ignimbrites, inherited zircon is absent in all units. This is in stark contrast with previous studies of Kizilkaya ignimbrite for which abundant Proterozoic-Archean zircon populations have been reported. Isotopic compositions of evolved magmas in the CAVP can be explained by interaction of mantle-derived basalt with post-Archean crust, with minor contributions of hydrothermally altered rocks. No tangible evidence exists for a magmatic contribution of Archean crustal components to the Mio-Pliocene ignimbrite flare-up in Central Anatolia, suggesting that regional basement rocks largely represent Gondwanan crust that was originally consolidated and subsequently became reprocessed during post-Archean times. (C) 2020 International Association for Gondwana Research. Published by Elsevier B.V. All rights reserved.