An overlooked parameter in coronary slow flow phenomenon: whole blood viscosity

Cetin M. S., Cetin E. H. O., Canpolat U., Aydin S., Temizhan A., Topaloglu S., ...More

BIOMARKERS IN MEDICINE, vol.9, no.12, pp.1311-1321, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 12
  • Publication Date: 2015
  • Doi Number: 10.2217/bmm.15.92
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1311-1321
  • Keywords: coronary slow flow phenomenon, shear rate, TIMI frame count, whole blood viscosity, SHEAR-STRESS, RISK-FACTORS, ASSOCIATION, MECHANISMS, RHEOLOGY, ARTERIES
  • Hacettepe University Affiliated: Yes


Aims: We aimed to assess the relationship between coronary slow flow phenomenon (CSFP) and whole blood viscosity (WBV). Materials & methods: Two hundred patients with CSFP and 200 subjects with normal coronary arteries as control group were enrolled. WBV was calculated from hematocrit and plasma protein concentration at low shear rate (LSR) (0.5 s(-1)) and high shear rate (HSR) (208 s(-1)) by a validated equation. Results: CSFP patients had significantly higher WBV for LSR and HSR. The mean corrected TIMI frame count was highest in the highest tertile group for both shear rates. Corrected TIMI frame count revealed a significant relationship with WBV for LSR (r = 0.562) and HSR (r = 0.611). At multivariate analysis, WBV at LSR and HSR were independent predictors of CSFP. Conclusion: WBV seemed to have a significant and an independent predictor of CSFP.