"Evaluation of Biochemical and Hematological Parameters Among Workers Occupationally Exposed to Toluene"

Bacaksız A., Tutkun E., Yılmaz Ö. H. , Yılmaz F. M. , Kartal Y., Söylemezoğlu T.

8th Turkish Society of Toxicology Congress, Antalya, Turkey, 15 - 18 November 2012, pp.76

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.76


Hippuric acid in urine is a worldwide used biomarker for the diagnosis and biomonitorization of occupational exposure to toluene. Especially, in non-hygienic conditions like the lack of workplace air monitoring and preventive measures, it is essential to establish the workers’ exposure to industrial solvents.

The aim of the study is to investigate the efficiency of biochemical and hematological parameters in biological monitoring of workers in annual periodical examinations. In this study, 380 workers from nine different sectors exposed to industrial toluene were selected as participants and urine hippuric acid levels were analyzed with HPLC. ALT, AST, creatinine and hemogram analyses were made by biochemical autoanalyser with commercial kits. Serum ALT, AST, creatinine, hemoglobin, lymphocyte, neutrophil, platelet levels were compared among groups whose hippuric acid urine levels which are ≤ 1000 μg/L and ≤ 2000 μg/L. An additional comparison were made between different occupations. No statistically significant difference was found between these groups. It is noteworthy to emphasize that, even in toxic blood levels, none of the biochemical and hematological parameters showed statistically significant changes. These results suggest that hematological and biochemical laboratory parameters are not effective prognostic markers in annual periodical examinations of workers and an effective parameter in diagnosis in emergency services. The unique valuable marker is hippuric acid levels in urine.