Metastasis suppressor proteins in cutaneous squamous cell carcinoma

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Bozdogan O., VARGEL İ., Cavusoglu T., Karabulut A. A., Karahan G., Sayar N., ...Daha Fazla

PATHOLOGY RESEARCH AND PRACTICE, cilt.212, sa.7, ss.608-615, 2016 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 212 Sayı: 7
• Basım Tarihi: 2016
• Doi Numarası: 10.1016/j.prp.2015.12.018
• Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.608-615
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Hacettepe Üniversitesi Adresli: Evet

Özet

Cutaneous squamous cell carcinomas (cSCCs) are common human carcinomas. Despite having metastasizing capacities, they usually show less aggressive progression compared to squamous cell carcinoma (SCC) of other organs. Metastasis suppressor proteins (MSPs) are a group of proteins that control and slow-down the metastatic process. In this study, we established the importance of seven well-defined MSPs including NDRG1, NM23-H1, RhoGDI2, E-cadherin, CD82/KAI1, MKK4, and AKAP12 in cSCCs.