Metastasis suppressor proteins in cutaneous squamous cell carcinoma

Bozdogan, Onder; VARGEL, İBRAHİM; Cavusoglu, Tarik; Karabulut, Ayse; Karahan, Gurbet; Sayar, Nilufer; Atasoy, Pinar; YULUĞ, IŞIK

doi:10.1016/j.prp.2015.12.018

Metastasis suppressor proteins in cutaneous squamous cell carcinoma

Bozdogan O., VARGEL İ., Cavusoglu T., Karabulut A. A., Karahan G., Sayar N., ...More

PATHOLOGY RESEARCH AND PRACTICE, vol.212, no.7, pp.608-615, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 212 Issue: 7
Publication Date: 2016
Doi Number: 10.1016/j.prp.2015.12.018
Journal Name: PATHOLOGY RESEARCH AND PRACTICE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.608-615
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

Cutaneous squamous cell carcinomas (cSCCs) are common human carcinomas. Despite having metastasizing capacities, they usually show less aggressive progression compared to squamous cell carcinoma (SCC) of other organs. Metastasis suppressor proteins (MSPs) are a group of proteins that control and slow-down the metastatic process. In this study, we established the importance of seven well-defined MSPs including NDRG1, NM23-H1, RhoGDI2, E-cadherin, CD82/KAI1, MKK4, and AKAP12 in cSCCs.