Metastasis suppressor proteins in cutaneous squamous cell carcinoma

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Bozdogan O., VARGEL İ., Cavusoglu T., Karabulut A. A., Karahan G., Sayar N., ...More

PATHOLOGY RESEARCH AND PRACTICE, vol.212, no.7, pp.608-615, 2016 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 212 Issue: 7
• Publication Date: 2016
• Doi Number: 10.1016/j.prp.2015.12.018
• Journal Name: PATHOLOGY RESEARCH AND PRACTICE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.608-615
• Open Archive Collection: AVESIS Open Access Collection
• Hacettepe University Affiliated: Yes

Abstract

Cutaneous squamous cell carcinomas (cSCCs) are common human carcinomas. Despite having metastasizing capacities, they usually show less aggressive progression compared to squamous cell carcinoma (SCC) of other organs. Metastasis suppressor proteins (MSPs) are a group of proteins that control and slow-down the metastatic process. In this study, we established the importance of seven well-defined MSPs including NDRG1, NM23-H1, RhoGDI2, E-cadherin, CD82/KAI1, MKK4, and AKAP12 in cSCCs.