The main purpose of this study which examines how it can be more effective in terms of organizational and managerial aspects with chambers of commerce and industry affiliated to The Union of Chambers and Commodity Exchanges of Turkey is to analyze the relationships between ethical leadership, work engagement, intrapreneurship, and service innovation behavior. In addition, it is to determine the role of mediation of work engagement effecting on intrapreneurship and service innovation behavior. For this purpose, quantitative analysis methods have been adopted. The data collected from 568 employees who were employed in chambers of commerce and industry operating in Turkey were analyzed. For the validity and reliability of the measurement tools, confirmatory factor analysis, the model?s good fit values and the AMOS Structural Equation Model were used. It was found that ethical leadership had statistically significant effect on employee engagement, intrapreneurship and the subscales of service innovation behavior (employee service innovation behavior and new service development). The results showed that work engagement partially mediated with ethical leadership effecting on intrapreneurship, ethical leadership effecting on the subscales of service innovation behavior. It is thought that the study is important in terms of providing empirical contributions to the ethical leadership, service innovation, intrapreneurship and work engagement literature. Finally, there are some limitations of the study and some suggestions are offered for future studies.