Amphricrine carcinoma of the cervix-adeno neuroendocrine tumor: A case report Servikal ampikrin adeno-nöroendokrin karsinom: Olgu sunumu

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FADILOĞLU E., Karalök A., Türkmen O., Asiltürk Ş., Öçalan R., Boran N., ...More

Turkish Journal of Obstetrics and Gynecology, vol.13, no.2, pp.99-102, 2016 (Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.4274/tjod.72325
  • Journal Name: Turkish Journal of Obstetrics and Gynecology
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.99-102
  • Keywords: Cervical carcinoma, amphicrine tumor, neuroendochrine tumor
  • Hacettepe University Affiliated: Yes


Adenoneuroendocrine carcinoma is a very rare form of cervical carcinoma that includes both endocrine and exocrine components. In general terms, these carcinomas progress aggressively and show early metastases due to the neuroendocrine component. The most important criteria related to prognosis is the stage of the disease. Without clearly determined therapeutic protocols this carcinoma is generally seen at earlier ages and causes high mortality. Many radiotherapy and multidrug chemotherapy protocols are used after surgical intervention. Detection of the neuroendocrine component of cervical tumors is achieved through immunohistochemical staining. Herein, we present a woman aged 50 years who was admitted to the hospital with abdominal pain and postmenopausal vaginal bleeding whose examination revealed a cervical tumor. A pathologic examination after surgery resulted as “adenocarcinoma and large cell neuroendocrine carcinoma.” Afterwards, a combined chemotherapy regimen (cisplatin + etoposid) was administered to the patient and 6 months of progress is evaluated in this report.