A facile in vitro model to study rapid mineralization in bone tissues
BIOMEDICAL ENGINEERING ONLINE, cilt.13, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13
- Basım Tarihi: 2014
- Doi Numarası: 10.1186/1475-925x-13-136
- Dergi Adı: BIOMEDICAL ENGINEERING ONLINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Osteoblasts, Rapid bone formation, Matrix mineralization, Cell aggregates, Aggregate size, EMBRYONIC STEM-CELLS, GENE-EXPRESSION, EXTRACELLULAR-MATRIX, DIFFERENTIATION, OSTEOBLASTS, FRACTURE, CULTURE, GROWTH, PHENOTYPE, VIVO
- Hacettepe Üniversitesi Adresli: Evet
Özet
Background: Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the final calcified tissue. An in vitro model to investigate the influencing factors is highly required.