A facile in vitro model to study rapid mineralization in bone tissues

Deegan A. J., Aydin H. M., Hu B., Konduru S., Kuiper J. H., Yang Y.

BIOMEDICAL ENGINEERING ONLINE, vol.13, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2014
  • Doi Number: 10.1186/1475-925x-13-136
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Osteoblasts, Rapid bone formation, Matrix mineralization, Cell aggregates, Aggregate size, EMBRYONIC STEM-CELLS, GENE-EXPRESSION, EXTRACELLULAR-MATRIX, DIFFERENTIATION, OSTEOBLASTS, FRACTURE, CULTURE, GROWTH, PHENOTYPE, VIVO
  • Hacettepe University Affiliated: Yes


Background: Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the final calcified tissue. An in vitro model to investigate the influencing factors is highly required.