A facile in vitro model to study rapid mineralization in bone tissues

Deegan A. J., Aydin H. M., Hu B., Konduru S., Kuiper J. H., Yang Y.

BIOMEDICAL ENGINEERING ONLINE, cilt.13, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1186/1475-925x-13-136
  • Dergi Adı: BIOMEDICAL ENGINEERING ONLINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Osteoblasts, Rapid bone formation, Matrix mineralization, Cell aggregates, Aggregate size, EMBRYONIC STEM-CELLS, GENE-EXPRESSION, EXTRACELLULAR-MATRIX, DIFFERENTIATION, OSTEOBLASTS, FRACTURE, CULTURE, GROWTH, PHENOTYPE, VIVO
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the final calcified tissue. An in vitro model to investigate the influencing factors is highly required.