Chitosan delivery systems for the treatment of oral mucositis: in vitro and in vivo studies.

Aksungur P., Sungur A., Unal S., Iskit A. B., Squier C., Senel S.

Journal of controlled release : official journal of the Controlled Release Society, cilt.98, sa.2, ss.269-79, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.jconrel.2004.05.002
  • Dergi Adı: Journal of controlled release : official journal of the Controlled Release Society
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.269-79
  • Anahtar Kelimeler: chitosan, nystatin, oral mucositis, gel, film, in vivo studies, DRUG-DELIVERY, CONTROLLED-RELEASE, MOLECULAR-WEIGHT, BIOADHESIVE, HYDROGELS, COMPLEX, CAVITY, BEADS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Oral mucositis is a frequent and potentially severe complication of radiation or chemotherapy for cancer. Associated with atrophy and ulceration of the oral mucosa is an increased risk of infection, and the most common pathogenic agent is Candida. Chitosan is an excellent candidate for the treatment of oral mucositis. Its bioadhesive and antimicrobial properties offer the palliative effects of an occlusive dressing and the potential for delivering drugs, including anti-candidal agents.