The Effect of Nitrogen Mustard on the Enzymatic Antioxidant Defense of Rat Brain Tissue and the Therapeutic Value of Proanthocyanidin

Tekiner A., Yucel D., Bayar M. A., Yucel O., Erdem Y., Karakaya J.

TURKISH NEUROSURGERY, cilt.21, sa.4, ss.461-466, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5137/1019-5149.jtn.4028-10.3
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.461-466
  • Hacettepe Üniversitesi Adresli: Evet

Özet

AIM: Nitrogen Mustard (NM) is an alkylating agent that damages cellular nuclear DNA after penetrating tissue. This results in cytostatic, mutagenic and cytotoxic effects. We used biochemical analyses to investigate the effect of NM gas administered through the dermal and respiratory routes, on the brain cortex of rats and also tried to show whether the antioxidant Proanthocyanidin (PC) could decrease this effect.