Objective. Familial Mediterranean fiver (FMF) attacks are characterized by serosal inflammation rich in PMNL leukocytes and activation of a definite cytokine network. Moreover there is sustained inflammation in attack-free FMF patients. Interleukin (IL)-17 and IL-18 art recently described proinflammatory cytokines, which Can modulate certain neutrophil functions. fit this study we measured serum levels of IL-17 and IL-18 in FMF patients.