Autoimmune hemolytic anemia and giant cell hepatitis: Report of three infants

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Ünal Ş., Kuşkonmaz B. B., Balamtekin N., Baysoy G., Aytaç E., Orhan D., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.27, no.4, pp.308-313, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.5152/tjh.2010.55
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.308-313
  • Hacettepe University Affiliated: Yes

Abstract

Giant cell hepatitis associated with direct Coombs' test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear. An autoimmune activation and loss of self-tolerance in these patients may be the underlying pathology related to the response of some of the patients to immunosuppressive treatment. Herein, we report the clinical presentation and course of three consecutive patients with this rare condition. We conclude that serum ferritin at diagnosis may be used for prediction of the outcome. (Turk J Hematol 2010; 27: 308-13)