Are MEFV mutations susceptibility factors in enthesitis-related arthritis patients in the eastern Mediterranean?

Gulhan B., Akkus A., Ozcakar L., Besbas N., Ozen S.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.32, no.4, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2014
  • Journal Name: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: enthesitis-related arthritis, familial Mediterranean fever, JUVENILE IDIOPATHIC ARTHRITIS, ANKYLOSING-SPONDYLITIS, FEVER GENE, SUBCLINICAL INFLAMMATION, POLYARTERITIS-NODOSA, DISEASE, CRITERIA, ASSOCIATION, PREVALENCE, FMF
  • Hacettepe University Affiliated: Yes

Abstract

Objective. Enthesitis-related arthritis (ERA), is a complex genetic disease. Although HLA-B27 is well established, it does not explain all the genetic load in ERA. Familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, is a frequent autoinflammatory disorder in the eastern Mediterranenan.