Obesity is defined as increased amount of energy sources stored as body fat in mammalians and human beings, to the extent that it may have adverse effects on health. It is very common around the world and a leading cause of morbidity and mortality. Excessive intake of calories, lack of exercise and genetic predisposition are the main causes, however, medical treatment and psychiatric conditions may infrequently result in obesity. There are many commercial products on the market to prevent obesity. Many products are effective when used together with diet and physical exercise, however, some are claimed to be effective without changing the lifestyle. Obesity bands are self adhesive transdermal products that are replaced every day or week, and are reported to help losing weight. These products contain herbal mixtures. The most common ingredients are combinations of Fucus vesiculosis, Guarana and Garcina cambogia. These patches may result in adverse effects when used inappropriately. Adverse effects may be serious in sensitive patients. In addition to adverse effects, they may cause delay in treatment. Since use of weight loss patches may prevent the treatment of obesity-related disorders that can be treated by diet, exercise and medical treatment, their usage may not be justified. Current review evaluates the ingredients of weight loss patches and toxicological results associated with use of these products.