Assessmento of DNA damage in benign and malignant breast tumours


ŞAHİN T. Ö. , Ündeǧer Ü., KURUKAHVECİOĞLU O., YÜKSEL O., BOSTANCI H., TEKİN E., ...More

Fabad Journal of Pharmaceutical Sciences, vol.34, no.3, pp.145-152, 2009 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2009
  • Journal Name: Fabad Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus
  • Page Numbers: pp.145-152

Abstract

Breast is the second most common site of cancer formation. It has been found that in patients with breast cancer DNA instability was enhanced and together with this enhanced damage, the DNA repair capacity which was estimated to contribute to the neoplastic transformation in the breast was decreased. The aim of the present study was to investigate the possible DNA damage in the peripheral lymphocytes among the patients with benign and malignant breast disorders in comparison to healthy controls by using the single cell gel electrophoresis (comet) assay. In this study, DNA damage of 28 patients with benign and 23 patients with malignant breast disorders operated in Gazi University, Medical Faculty, Department of Surgery were compared with 30 healthy controls comparable in sex, socioeconomic status and smoking habits with no history of any breast disease. Significant increases were observed in DNA damage in patients with benign and malignant breast disorders compared to the healthy controls. No significant difference was found between benign and malignant breast disorders.