The asymmetric unit of the title mononuclear Cu-II complex, [Cu(C7H4FO2)(2)(C10H14N2O)(2)(H2O)(2)], contains one-half of the molecule. The Cu-II ion is located on an inversion centre, and is coordinated by two N atoms from two diethylnicotinamide ligands, two O atoms from two 4-fluorobenzoate (PFB) ligands and two water molecules in a distorted octahedral geometry. In the PFB ligand, the carboxylate group is twisted at an angle of 2.10 (14)degrees from the attached benzene ring. In the crystal structure, intermolecular O-H center dot center dot center dot O hydrogen bonds link molecules related by translation along the a axis into chains. Weak intermolecular C-H center dot center dot center dot O hydrogen bonds and pi-pi interactions between the pyridine rings of neighbouring molecules [centroid-to-centroid distance = 3.571 (2) angstrom] further consolidate the crystal packing.