Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response

Grafanaki K., Grammatikakis I., Ghosh A., Gopalan V., Olgun G., Liu H., ...More

Pharmacology and Therapeutics, vol.248, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 248
  • Publication Date: 2023
  • Doi Number: 10.1016/j.pharmthera.2023.108466
  • Journal Name: Pharmacology and Therapeutics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, CAB Abstracts, Chemical Abstracts Core, International Pharmaceutical Abstracts, Veterinary Science Database, DIALNET
  • Keywords: Circular RNAs (circRNAs), Developmental state, Lineage, Long non-coding RNAs (lncRNAs), Melanoma, microRNAs (miRNAs), Non-coding RNAs (ncRNAs), Plasticity, Translational plasticity
  • Hacettepe University Affiliated: Yes


Melanoma, the cancer of the melanocyte, is the deadliest form of skin cancer with an aggressive nature, propensity to metastasize and tendency to resist therapeutic intervention. Studies have identified that the re-emergence of developmental pathways in melanoma contributes to melanoma onset, plasticity, and therapeutic response. Notably, it is well known that noncoding RNAs play a critical role in the development and stress response of tissues. In this review, we focus on the noncoding RNAs, including microRNAs, long non-coding RNAs, circular RNAs, and other small RNAs, for their functions in developmental mechanisms and plasticity, which drive onset, progression, therapeutic response and resistance in melanoma. Going forward, elucidation of noncoding RNA-mediated mechanisms may provide insights that accelerate development of novel melanoma therapies.