Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients


Yilmaz D., Yuksel D., Gokkurt D., Oguz H., Anlar B.

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, vol.20, no.4, pp.611-615, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ejpn.2016.03.007
  • Journal Name: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.611-615

Abstract

Purpose: Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal disease. Brain histopathology in certain SSPE patients shows, neurofibrillary tangles composed of abnormally phosphorylated, microtubule-associated protein tau (PHF-tau). Because the, phosphorylation of tau is inhibited by insulin and insulin-like growth factor-1 (IGF-1), we investigated cerebrospinal fluid (CSF) insulin and IGF-1 levels in SSPE patients.