Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients

Yilmaz, Deniz; Yuksel, Deniz; Gokkurt, Didem; Oguz, Hava; Anlar, Banu

doi:10.1016/j.ejpn.2016.03.007

Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients

Yilmaz D., Yuksel D., Gokkurt D., Oguz H., Anlar B.

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, vol.20, no.4, pp.611-615, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 20 Issue: 4
Publication Date: 2016
Doi Number: 10.1016/j.ejpn.2016.03.007
Journal Name: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.611-615
Hacettepe University Affiliated: Yes

Abstract

Purpose: Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal disease. Brain histopathology in certain SSPE patients shows, neurofibrillary tangles composed of abnormally phosphorylated, microtubule-associated protein tau (PHF-tau). Because the, phosphorylation of tau is inhibited by insulin and insulin-like growth factor-1 (IGF-1), we investigated cerebrospinal fluid (CSF) insulin and IGF-1 levels in SSPE patients.