Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients

Yilmaz, Deniz; Yuksel, Deniz; Gokkurt, Didem; Oguz, Hava; Anlar, Banu

doi:10.1016/j.ejpn.2016.03.007

Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients

Copy For Citation

Yilmaz D., Yuksel D., Gokkurt D., Oguz H., Anlar B.

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, vol.20, no.4, pp.611-615, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 20 Issue: 4
Publication Date: 2016
Doi Number: 10.1016/j.ejpn.2016.03.007
Journal Name: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.611-615
Hacettepe University Affiliated: Yes

Abstract

Purpose: Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal disease. Brain histopathology in certain SSPE patients shows, neurofibrillary tangles composed of abnormally phosphorylated, microtubule-associated protein tau (PHF-tau). Because the, phosphorylation of tau is inhibited by insulin and insulin-like growth factor-1 (IGF-1), we investigated cerebrospinal fluid (CSF) insulin and IGF-1 levels in SSPE patients.