Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients

Yilmaz, Deniz; Yuksel, Deniz; Gokkurt, Didem; Oguz, Hava; Anlar, Banu

doi:10.1016/j.ejpn.2016.03.007

Increased insulin-like growth factor-1 levels in cerebrospinal fluid of advanced subacute sclerosing panencephalitis patients

Yilmaz D., Yuksel D., Gokkurt D., Oguz H., Anlar B.

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, cilt.20, sa.4, ss.611-615, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 4
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.ejpn.2016.03.007
Dergi Adı: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.611-615
Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: Subacute sclerosing panencephalitis (SSPE) is a progressive, lethal disease. Brain histopathology in certain SSPE patients shows, neurofibrillary tangles composed of abnormally phosphorylated, microtubule-associated protein tau (PHF-tau). Because the, phosphorylation of tau is inhibited by insulin and insulin-like growth factor-1 (IGF-1), we investigated cerebrospinal fluid (CSF) insulin and IGF-1 levels in SSPE patients.