Voltammetric oxidation of ambroxol and application to its determination in pharmaceuticals and in drug dissolution studies

Demircigil B., Uslu B., Ozkan Y., Ozkan S., Senturk Z.

ELECTROANALYSIS, cilt.15, sa.3, ss.230-234, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1002/elan.200390029
  • Dergi Adı: ELECTROANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.230-234
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

A detailed study of the electrochemistry of ambroxol at a glassy carbon electrode was carried out in the pH range 1.8 - 11.0 in aqueous solution using cyclic and differential pulse voltammetry. The compound was oxidized irreversibly at high positive potentials resulting in the formation of a chemical product at less positive potentials, which was more readily oxidized than the parent compound. In addition, a differential pulse voltammetric method was proposed for the determination of the drug in different pharmaceutical formulations, and in drug dissolution studies.