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Ozer E. K., GÜNDÜZ M. G., El-Khouly A., Sara Y., ŞİMŞEK R., İSKİT A. B., ...More
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.43, no.6, pp.578-586, 2018 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
43
Issue:
6
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Publication Date:
2018
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Doi Number:
10.1515/tjb-2016-0247
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Journal Name:
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
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Page Numbers:
pp.578-586
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Keywords:
1,4-Dihydropyridine, Calcium channel, Hexahydroquinoline, Isolated aortic rings, Relaxant effects, MICROWAVE-ASSISTED SYNTHESIS, RABBIT GASTRIC FUNDUS, MYORELAXANT ACTIVITY, MEDICINAL CHEMISTRY, DERIVATIVES, ANTAGONIST, MODULATORS, SCAFFOLD, LIGANDS, STORY
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Hacettepe University Affiliated:
Yes
Abstract
Objective: The aim of this study was to synthesize ten 1,4-dihydropyridine (DHP) derivatives in which substituted cyclohexane rings were fused to the DHP ring and to determine how different ester groups and the benzoyl substituent introduced in 4-phenyl ring affected their calcium channel blocking activity.