Synthesis of fused 1,4-dihydropyridines as potential calcium channel blockers


Ozer E. K. , GÜNDÜZ M. G. , El-Khouly A., Sara Y., ŞİMŞEK R., İSKİT A. B. , ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.43, no.6, pp.578-586, 2018 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1515/tjb-2016-0247
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.578-586
  • Keywords: 1,4-Dihydropyridine, Calcium channel, Hexahydroquinoline, Isolated aortic rings, Relaxant effects, MICROWAVE-ASSISTED SYNTHESIS, RABBIT GASTRIC FUNDUS, MYORELAXANT ACTIVITY, MEDICINAL CHEMISTRY, DERIVATIVES, ANTAGONIST, MODULATORS, SCAFFOLD, LIGANDS, STORY

Abstract

Objective: The aim of this study was to synthesize ten 1,4-dihydropyridine (DHP) derivatives in which substituted cyclohexane rings were fused to the DHP ring and to determine how different ester groups and the benzoyl substituent introduced in 4-phenyl ring affected their calcium channel blocking activity.