Synthesis of fused 1,4-dihydropyridines as potential calcium channel blockers


Ozer E. K. , GÜNDÜZ M. G. , El-Khouly A., Sara Y., ŞİMŞEK R. , İSKİT A. B. , ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.43, sa.6, ss.578-586, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 43 Konu: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1515/tjb-2016-0247
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Sayfa Sayıları: ss.578-586

Özet

Objective: The aim of this study was to synthesize ten 1,4-dihydropyridine (DHP) derivatives in which substituted cyclohexane rings were fused to the DHP ring and to determine how different ester groups and the benzoyl substituent introduced in 4-phenyl ring affected their calcium channel blocking activity.