The Mediterranean region has been increasingly receiving attention in recent years. This is due to the heterogeneity of the countries composing it, which raises several problems in business collaborations, but also unfolds several cross-national economic opportunities among Mediterranean countries. The analysis of cultural and creative industries can be useful to show that this area has many similarities, making intercultural exchange and cross-national economic development possible. This research starts from the comparison of three main Mediterranean countries situated both in Europe and outside, Italy, Spain and Turkey, and aims at highlighting the most striking similarities and differences of their features. The creativity specialization found in this region is alike, which allows us to begin to discuss the idea of a Mediterranean creativity.