Empiric Therapy With Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum beta-Lactamase-Producing Enterobacteriaceae: Results From the INCREMENT Cohort

Raquel Palacios-Baena, Zaira; Gutierrez-Gutierrez, Belen; Calbo, Esther; Almirante, Benito; Viale, Pierluigi; Oliver, Antonio; Pintado, Vicente; Gasch, Oriol; Martinez-Martinez, Luis; Pitout, Johann; AKOVA, MURAT; Pena, Carmen; Molina Gil-Bermejo, Jose; Hernandez, Alicia; Venditti, Mario; Prim, Nuria; Bou, German; Tacconelli, Evelina; Tumbarello, Mario; Hamprecht, Axel; Giamarellou, Helen; Almela, Manel; Perez, Federico; Schwaber, Mitchell; Bermejo, Joaquin; Lowman, Warren; Hsueh, Po-Ren; Ramon Pano-Pardo, Jose; Torre-Cisneros, Julian; Souli, Maria; Bonomo, Robert; Carmeli, Yehuda; Paterson, David; Pascual, Alvaro; Rodriguez-Bano, Jesus

doi:10.1093/cid/cix606

Empiric Therapy With Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum beta-Lactamase-Producing Enterobacteriaceae: Results From the INCREMENT Cohort

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Raquel Palacios-Baena Z., Gutierrez-Gutierrez B., Calbo E., Almirante B., Viale P., Oliver A., ...More

CLINICAL INFECTIOUS DISEASES, vol.65, no.10, pp.1615-1623, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 65 Issue: 10
Publication Date: 2017
Doi Number: 10.1093/cid/cix606
Journal Name: CLINICAL INFECTIOUS DISEASES
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1615-1623
Hacettepe University Affiliated: Yes

Abstract

Background. There is little information about the efficacy of active alternative drugs to carbapenems except beta-lactam/beta-lactamase inhibitors for the treatment of bloodstream infections (BSIs) due to extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E). The objective of this study was to assess the outcomes of patients with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OADs]) or carbapenems.