Impact of mannose-binding lectin 2 gene polymorphisms on disease severity in noncystic fibrosis bronchiectasis in children


Dogru D. , Polat S. E. , Tan Ç., Tezcan İ., Yalçın S. S. , Utine E., ...Daha Fazla

PEDIATRIC PULMONOLOGY, cilt.55, sa.5, ss.1190-1198, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 55 Konu: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/ppul.24711
  • Dergi Adı: PEDIATRIC PULMONOLOGY
  • Sayfa Sayıları: ss.1190-1198

Özet

Background Mannose-binding lectin (MBL) is a complement protein involved in the innate immune system, and is associated with some chronic respiratory diseases including noncystic fibrosis (non-CF) bronchiectasis in adults. The aim of this study was to investigate the frequency of MBL2 gene polymorphisms in children with non-CF bronchiectasis, and the effect of MBL deficiency on disease severity.