Impact of mannose-binding lectin 2 gene polymorphisms on disease severity in noncystic fibrosis bronchiectasis in children

Dogru D., Polat S. E., Tan Ç., Tezcan İ., Yalçın S. S., Utine E., ...Daha Fazla

PEDIATRIC PULMONOLOGY, cilt.55, sa.5, ss.1190-1198, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/ppul.24711
  • Dergi Adı: PEDIATRIC PULMONOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1190-1198
  • Anahtar Kelimeler: children, gene polymorphism, mannose-binding lectin, noncystic fibrosis bronchiectasis, CYSTIC-FIBROSIS, DEFICIENCY, SYSTEM
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background Mannose-binding lectin (MBL) is a complement protein involved in the innate immune system, and is associated with some chronic respiratory diseases including noncystic fibrosis (non-CF) bronchiectasis in adults. The aim of this study was to investigate the frequency of MBL2 gene polymorphisms in children with non-CF bronchiectasis, and the effect of MBL deficiency on disease severity.