Impact of mannose-binding lectin 2 gene polymorphisms on disease severity in noncystic fibrosis bronchiectasis in children
PEDIATRIC PULMONOLOGY, cilt.55, sa.5, ss.1190-1198, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 55 Sayı: 5
- Basım Tarihi: 2020
- Doi Numarası: 10.1002/ppul.24711
- Dergi Adı: PEDIATRIC PULMONOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1190-1198
- Anahtar Kelimeler: children, gene polymorphism, mannose-binding lectin, noncystic fibrosis bronchiectasis, CYSTIC-FIBROSIS, DEFICIENCY, SYSTEM
- Hacettepe Üniversitesi Adresli: Evet
Özet
Background Mannose-binding lectin (MBL) is a complement protein involved in the innate immune system, and is associated with some chronic respiratory diseases including noncystic fibrosis (non-CF) bronchiectasis in adults. The aim of this study was to investigate the frequency of MBL2 gene polymorphisms in children with non-CF bronchiectasis, and the effect of MBL deficiency on disease severity.