Detrimental effects of nitric oxide on mesenteric circulation during endotoxaemia and its reversal by aminoguanidine
EUROPEAN JOURNAL OF SURGERY, vol.166, no.11, pp.888-893, 2000 (SCI-Expanded)
- Publication Type: Article / Article
- Volume: 166 Issue: 11
- Publication Date: 2000
- Doi Number: 10.1080/110241500447290
- Journal Name: EUROPEAN JOURNAL OF SURGERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
- Page Numbers: pp.888-893
- Hacettepe University Affiliated: No
Abstract
Objective: To investigate the effect of endotoxaemia on rat mesenteric vascular bed and plasma nitrite concentrations, the possible beneficial effect of aminoguanidine (the selective inducible nitric oxide synthase inhibitor) compared with N-G-nitro-L-arginine methyl ester (L-NAME) (non-selective nitric oxide synthase inhibitor).