Detrimental effects of nitric oxide on mesenteric circulation during endotoxaemia and its reversal by aminoguanidine


Yorganci K., Sayek I., Ismailoglu U., Sahin-Erdemli I.

EUROPEAN JOURNAL OF SURGERY, vol.166, no.11, pp.888-893, 2000 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 166 Issue: 11
  • Publication Date: 2000
  • Doi Number: 10.1080/110241500447290
  • Journal Name: EUROPEAN JOURNAL OF SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.888-893
  • Hacettepe University Affiliated: No

Abstract

Objective: To investigate the effect of endotoxaemia on rat mesenteric vascular bed and plasma nitrite concentrations, the possible beneficial effect of aminoguanidine (the selective inducible nitric oxide synthase inhibitor) compared with N-G-nitro-L-arginine methyl ester (L-NAME) (non-selective nitric oxide synthase inhibitor).