ALOX5 promoter genotype, asthma severity and LTC4 production by eosinophils

KALAYCI, ÖMER; Birben, ESRA; Sackesen, CANSIN; KESKİN, ÖZLEM; TAHAN, FULYA; WECHSLER, MİCHAEL; Civelek, ERSOY; Soyer, OU; Adalioglu, GÖNÜL; TUNCER, AYFER; ISRAEL, ELLİOT; LİLLY, CRAİG

doi:10.1111/j.1398-9995.2006.00979.x

ALOX5 promoter genotype, asthma severity and LTC4 production by eosinophils

KALAYCI Ö., Birben E., Sackesen C., KESKİN Ö., TAHAN F., WECHSLER M. E., ...Daha Fazla

ALLERGY, cilt.61, sa.1, ss.97-103, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 61 Sayı: 1
Basım Tarihi: 2006
Doi Numarası: 10.1111/j.1398-9995.2006.00979.x
Dergi Adı: ALLERGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.97-103
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: The number of Sp1-Egr1 binding tandem repeats at the ALOX5 promoter influences gene transcription and may modify the response to anti-leukotriene treatment. The relationship of ALOX5 variants to asthma severity and leukotriene production by eosinophils is unknown.