Post-stroke inflammatory response is linked to volume loss in the contralateral hemisphere.

Okar S., TOPÇUOĞLU M. A., Yemisci M., Aktas C., Oguz K. K., ARSAVA E. M.

Journal of neuroimmunology, cilt.344, ss.577247, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 344
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jneuroim.2020.577247
  • Dergi Adı: Journal of neuroimmunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Sayfa Sayıları: ss.577247
  • Anahtar Kelimeler: Cerebrovascular diseases, Immunology, Infections, Neuroimaging, Strokes, ISCHEMIC-STROKE, MOTOR RECOVERY, BRAIN, IMMUNE, INJURY, CLASSIFICATION, PATHOLOGY, OUTCOMES, ATROPHY, PROTEIN
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objectives: There is a delicate homeostatic balance between the central nervous system and immune system. Stroke triggers an immunodepressive state to suppress a potential immune reaction directed against neuroglial tissue; however, this supposedly protective response inadvertently results in an infection-prone, and thereby a pro-inflammatory setting. In this study, we assessed the magnitude of cerebral volume loss in the unaffected contralateral hemisphere following stroke, and determined its relationship with inflammatory cascades.