Gestation specific reference intervals for thyroid function tests in pregnancy

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Akarsu S., Akbiyik F., Karaismailoglu E., DİKMEN Z. G.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.54, no.8, pp.1377-1383, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 54 Issue: 8
• Publication Date: 2016
• Doi Number: 10.1515/cclm-2015-0569
• Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1377-1383
• Hacettepe University Affiliated: Yes

Abstract

Background: Thyroid function tests are frequently assessed during pregnancy to evaluate thyroid dysfunction or to monitor pre-existing thyroid disease. However, using non-pregnant reference intervals can lead to misclassification. International guidelines recommended that institutions should calculate their own pregnancy-specific reference intervals for free thyroxine (FT4), free triiodothyronine (FT3) and thyroid-stimulating hormone (TSH). The objective of this study is to establish gestation-specific reference intervals (GRIs) for thyroid function tests in pregnant Turkish women and to compare these with the age-matched non-pregnant women.