Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

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Tsai P., Glastonbury C. A., Eliot M. N., Bollepalli S., YET İ., Castillo-Fernandez J. E., ...More

CLINICAL EPIGENETICS, vol.10, 2018 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 10
• Publication Date: 2018
• Doi Number: 10.1186/s13148-018-0558-0
• Journal Name: CLINICAL EPIGENETICS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Keywords: Smoking, DNA methylation, Gene expression, RNA-sequencing, Adipose tissue, EPIGENOME-WIDE ASSOCIATION, GENOTYPE IMPUTATION, MATERNAL SMOKING, AHRR METHYLATION, LUNG-TISSUE, ALCOHOL, CANCER, CYP1A1, LOCI, SIGNATURES
• Hacettepe University Affiliated: Yes

Abstract

Background: Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic health, remains unclear.