Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

Tsai P., Glastonbury C. A., Eliot M. N., Bollepalli S., YET İ., Castillo-Fernandez J. E., ...Daha Fazla

CLINICAL EPIGENETICS, cilt.10, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1186/s13148-018-0558-0
  • Dergi Adı: CLINICAL EPIGENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Smoking, DNA methylation, Gene expression, RNA-sequencing, Adipose tissue, EPIGENOME-WIDE ASSOCIATION, GENOTYPE IMPUTATION, MATERNAL SMOKING, AHRR METHYLATION, LUNG-TISSUE, ALCOHOL, CANCER, CYP1A1, LOCI, SIGNATURES
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic health, remains unclear.