Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review

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Rabiee N., Ahmadi S., Arab Z., Bagherzadeh M., Safarkhani M., Nasseri B., ...Daha Fazla

INTERNATIONAL JOURNAL OF NANOMEDICINE, cilt.15, ss.4237-4256, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2147/ijn.s248736
  • Dergi Adı: INTERNATIONAL JOURNAL OF NANOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.4237-4256
  • Hacettepe Üniversitesi Adresli: Evet

Özet

With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.