Quality of life is a multidimensional, sophisticated, comprehensive and abstract concept that reflects life conditions, health and social welfare status, perception of life and psychology of individuals. It is affected by health problem and disease existence as well as individual, demographic, economic and social characteristics such as gender, education, marital status and income level. The objective of this study is to determine the more likely predictors of the quality of life in Turkey. 2016 Turkey Health Survey that is a large and nationally representative survey was used to reach study objective. The results indicated that individual and demographic characteristic as well as self-rated health status and disease existence were the main predictors of quality of life. Based on the findings, it can be recommended that appropriate interventions might improve quality of life which is tend to be lower among aged, female, less educated and widow/separated individuals. It is also recommended in improving health status of individuals and improving accessibility, and quality of the health services for people with a disease will increase the quality of life of individuals.