The Formulation of Methylene Blue Encapsulated, Tc-99m Labeled Multifunctional Liposomes for Sentinel Lymph Node Imaging and Therapy


SİLİNDİR GÜNAY M.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, ss.381-387, 2020 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 17 Konu: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2019.86619
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Sayfa Sayıları: ss.381-387

Özet

Objectives: Methylene blue (MB) is a commonly used dye that can be used for near-infrared (NIR) imaging and photodynamic therapy (PDT) by producing reactive oxygen species after light exposure, inducing apoptosis. The limiting factor of MB is its poor penetration through cell membranes. Its decreased cellular uptake can be prevented by encapsulation in drug delivery systems such as liposomes. Additionally, the enhanced permeability and retention effect of tumors enables enhanced accumulation of nanocarriers at the target site.