The Formulation of Methylene Blue Encapsulated, Tc-99m Labeled Multifunctional Liposomes for Sentinel Lymph Node Imaging and Therapy
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.4, pp.381-387, 2020 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 17 Issue: 4
- Publication Date: 2020
- Doi Number: 10.4274/tjps.galenos.2019.86619
- Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Page Numbers: pp.381-387
- Open Archive Collection: AVESIS Open Access Collection
- Hacettepe University Affiliated: Yes
Abstract
Objectives: Methylene blue (MB) is a commonly used dye that can be used for near-infrared (NIR) imaging and photodynamic therapy (PDT) by producing reactive oxygen species after light exposure, inducing apoptosis. The limiting factor of MB is its poor penetration through cell membranes. Its decreased cellular uptake can be prevented by encapsulation in drug delivery systems such as liposomes. Additionally, the enhanced permeability and retention effect of tumors enables enhanced accumulation of nanocarriers at the target site.