Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies


Karuppasamy M., Mahapatra M., YABANOĞLU ÇİFTÇİ S. , UÇAR G. , Sinha B. N. , Basu A., ...Daha Fazla

BIOORGANIC & MEDICINAL CHEMISTRY, cilt.18, ss.1875-1881, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 18 Konu: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.bmc.2010.01.043
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY
  • Sayfa Sayıları: ss.1875-1881

Özet

3,5-Diaryl pyrazolines analogs were synthesized and evaluated for their monoamine oxidase (MAO) inhibitory activity. The compounds were found reversible and selective towards MAO-A with selectivity index in the magnitude of 10(3)-10(5). The docking studies were carried out to gain further structural insights of the binding mode and possible interactions with the active site of MAO-A. Interestingly, the theoretical (K-i) values obtained by molecular docking studies were in congruence with their experimental (K-i) values. (C) 2010 Elsevier Ltd. All rights reserved.