Physical evidence on desmin-lamin B interaction
CYTOSKELETON, cilt.78, sa.1, ss.14-17, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 1
- Basım Tarihi: 2021
- Doi Numarası: 10.1002/cm.21651
- Dergi Adı: CYTOSKELETON
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.14-17
- Anahtar Kelimeler: desmin, immunoprecipitation, lamin B, muscle, zebrafish
- Hacettepe Üniversitesi Adresli: Evet
Özet
Desmin is a muscle specific intermediate filament protein located in cytoplasm. Lamin B, on the other hand, is a nuclear intermediate filament protein. There are studies suggesting a possible interaction between desmin and lamin B yet there is no physical evidence. In the present study, we have shown for the first time a physical interaction between desmin and lamin B via reciprocal co-immunoprecipitation from muscle tissue of wild type AB zebrafish (Danio rerio, Hamilton). The interaction between desmin and lamin B might be a lead on a novel nucleocytoplasmic communication network.