Physical evidence on desmin-lamin B interaction

KURAL MANGIT E., DİNÇER P. R.

CYTOSKELETON, cilt.78, sa.1, ss.14-17, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1002/cm.21651
  • Dergi Adı: CYTOSKELETON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.14-17
  • Anahtar Kelimeler: desmin, immunoprecipitation, lamin B, muscle, zebrafish
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Desmin is a muscle specific intermediate filament protein located in cytoplasm. Lamin B, on the other hand, is a nuclear intermediate filament protein. There are studies suggesting a possible interaction between desmin and lamin B yet there is no physical evidence. In the present study, we have shown for the first time a physical interaction between desmin and lamin B via reciprocal co-immunoprecipitation from muscle tissue of wild type AB zebrafish (Danio rerio, Hamilton). The interaction between desmin and lamin B might be a lead on a novel nucleocytoplasmic communication network.