Studies on 2-ethyl-3-carbmethoxy-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives and calcium modulatory activities


Safak C. , Dogan E. , Erol K.

TURKISH JOURNAL OF CHEMISTRY, cilt.30, sa.1, ss.109-117, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Konu: 1
  • Basım Tarihi: 2006
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.109-117

Özet

Twelve new compounds having a 2-ethyl-3-carbmethoxy-4-aryl-5-oxo-1,4 5 6,7,8-hexahydroquinoline structure were synthesized, characterized and screened for their calcium modulatory activities. The calcium antagonistic activities of the compounds were investigated by tests performed on isolated rat ileum and lamb carotid artery. Compounds 1, 4, 8 and 9 showed considerable activity.