Studies on 2-ethyl-3-carbmethoxy-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives and calcium modulatory activities

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Safak C., Dogan E., Erol K.

TURKISH JOURNAL OF CHEMISTRY, vol.30, no.1, pp.109-117, 2006 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 30 Issue: 1
• Publication Date: 2006
• Journal Name: TURKISH JOURNAL OF CHEMISTRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.109-117
• Hacettepe University Affiliated: Yes

Abstract

Twelve new compounds having a 2-ethyl-3-carbmethoxy-4-aryl-5-oxo-1,4 5 6,7,8-hexahydroquinoline structure were synthesized, characterized and screened for their calcium modulatory activities. The calcium antagonistic activities of the compounds were investigated by tests performed on isolated rat ileum and lamb carotid artery. Compounds 1, 4, 8 and 9 showed considerable activity.