SYNTHESIS-STUTTGART, vol.45, no.2, pp.193-198, 2013 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
phosphonates, pyrrolizinones, Michael addition, metal triflates, heteroaromatic compounds, CYCLOPENTANE ANNULATED COMPOUNDS, EFFICIENT SYNTHESIS, REGIOSELECTIVE ALKYLATION, BIOLOGICAL-ACTIVITY, CONJUGATE ADDITION, PYRROLES, PHOSPHONATES, CONDENSATION, DERIVATIVES, PRODUCTS
Hacettepe University Affiliated:
Novel phosphonate compounds were synthesized via Michael addition of N-heteroaromatic compounds to aryl-and alkyl-substituted vinylphosphonates using scandium triflate as the catalyst. Intramolecular cyclization reaction of the Michael adducts obtained gives novel (dimethoxyphosphoryl) pyrrolizin-3-ones in high yields as a single diastereomer.