PAX8 (+)/p63 (-) Immunostaining Pattern in Renal Collecting Duct Carcinoma (CDC) A Useful Immunoprofile in the Differential Diagnosis of CDC Versus Urothelial Carcinoma of Upper Urinary Tract


Albadine R., Schultz L., Illei P., Ertoy D., Hicks J., Sharma R., ...Daha Fazla

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, cilt.34, sa.7, ss.965-969, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/pas.0b013e3181dc5e8a
  • Dergi Adı: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
  • Sayfa Sayıları: ss.965-969

Özet

Background: Collecting duct carcinoma (CDC) is a relatively rare but aggressive type of renal malignancy with variable morphologic features. One of the World Health Organization diagnostic criteria for CDC is the exclusion of urothelial carcinoma of renal pelvis from the differential diagnosis. PAX8 is a novel lineage restricted transcription factor expressed in renal tubules. We investigated the expression pattern of PAX8 in CDC and its utility, in combination with p63, in resolving the differential diagnosis of CDC versus upper tract urothelial carcinoma (UUC).