PAX8 (+)/p63 (-) Immunostaining Pattern in Renal Collecting Duct Carcinoma (CDC) A Useful Immunoprofile in the Differential Diagnosis of CDC Versus Urothelial Carcinoma of Upper Urinary Tract

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Albadine R., Schultz L., Illei P., Ertoy D., Hicks J., Sharma R., ...Daha Fazla

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, cilt.34, sa.7, ss.965-969, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/pas.0b013e3181dc5e8a
  • Dergi Adı: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.965-969
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Collecting duct carcinoma (CDC) is a relatively rare but aggressive type of renal malignancy with variable morphologic features. One of the World Health Organization diagnostic criteria for CDC is the exclusion of urothelial carcinoma of renal pelvis from the differential diagnosis. PAX8 is a novel lineage restricted transcription factor expressed in renal tubules. We investigated the expression pattern of PAX8 in CDC and its utility, in combination with p63, in resolving the differential diagnosis of CDC versus upper tract urothelial carcinoma (UUC).