Studies on the synthesis of some dihydropyridine derivatives possessing calcium antagonistic activity

KILCIGIL G., ERTAN R., Ozbey S., KENDI E.

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol.35, no.6, pp.1485-1492, 1998 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 1998
  • Doi Number: 10.1002/jhet.5570350645
  • Journal Name: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1485-1492
  • Hacettepe University Affiliated: Yes

Abstract

In this study, it is aimed to investigate the synthesis and the calcium antagonistic activity of some flavone derivatives which contain the 1,4-dihydropyridine ring system at the A ring of the flavone nucleus. For this purpose we first synthesized 6-formylflavone and then twelve 1,4-dihydropyridine derivatives were synthesized by the reaction of 6-formylflavone with alkylacetoacetates, acetoacetanilide and methyl or ethyl aminocrotonate. Conformational analysis was performed for compound 3a. The calcium antagonistic activity of compound 2a was examined using nifedipine as the reference compound.