The relationship between the presence of ADHD and certain candidate gene polymorphisms in a Turkish sample


Pazvantoglu O., GÜNEŞ S., Karabekiroglu K., Yegin Z., Erenkus Z., Akbas S., ...Daha Fazla

GENE, cilt.528, ss.320-327, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 528 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.gene.2013.07.004
  • Dergi Adı: GENE
  • Sayfa Sayıları: ss.320-327

Özet

Due to the high heritability of attention-deficit hyperactivity disorder (ADHD), parents of children with ADHD appear to represent a good sample group for investigating the genetics of the disorder. The aim of this study was to investigate the association between ADHD and six polymorphisms in five candidate genes [5-HT2A (rs6311), NET1 (rs2242447), COMT (rs4818), NTF3 (rs6332), SNAP-25 (rs3746544) and (rs1051312)]. We included 228 parents of children diagnosed with ADHD and 109 healthy parents as the control group. The polymorphisms were genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) assays and analyzed using the chi-square test and the multinomial logit model. SNAP-25 (rs3746544) polymorphism was associated with loading for ADHD, while 5-HT2A (rs6311) and NET1 (rs2242447) polymorphisms were associated with ADHD. On the other hand, there was no significant association between the SNAP-25 (rs1051312), NTF3 (rs6332), or COMT (rs4818) gene polymorphisms and ADHD.