Anaphylactic reaction to polyethylene-glycol conjugated-asparaginase: Premedication and desensitization may not be sufficient


ŞAHİNER Ü. M. , YAVUZ S. , Gokce M., Buyuktiryaki B. , Altan I. , Aytac S., ...Daha Fazla

PEDIATRICS INTERNATIONAL, cilt.55, sa.4, ss.531-533, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 55 Konu: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1111/ped.12131
  • Dergi Adı: PEDIATRICS INTERNATIONAL
  • Sayfa Sayıları: ss.531-533

Özet

In hypersensitive reactions to native L-asparaginase, either premedication and desensitization or substitution with polyethylene glycol conjugated asparaginase (PEG-ASP) is preferred. Anaphylaxis with PEG-ASP is rare. An 8-year-old girl and a 2.5-year-old boy, both diagnosed as having acute lymphoblastic leukemia, presented with native L-asparaginase hypersensitivity and substitution with PEG-ASP was preferred. They received a premedication (methylprednisolone, hydroxyzine and ranitidine) followed by desensitization with PEG-ASP infusion. Both patients developed anaphylaxis with peg-asparaginase. These are the first reported cases of anaphylactic reaction to PEG-ASP, despite the application of both premedication and desensitization. Anaphylaxis with PEG-ASP is very rare and premedication and desensitization protocols may not prevent these hypersensitive reactions.