Klimik Dergisi, vol.35, no.2, pp.55-63, 2022 (ESCI)
© 2022, DOC Design and Informatics Co. Ltd.. All rights reserved.The worldwide spread of multidrug-resistant /extensively drug-resistant Pseudomonas aeruginosa high-risk clones is a global health threat. P. aeruginosa has an evident capacity for developing antimicrobial resistance to nearly all available antipseudomonal agents through the selection of chromosomal mutations. Analysis of whole genome sequencing mutational resistomes has proven to be useful for understanding the evolutionary dynamics of antibiotic resistance mechanisms and characterization of widespread epidemic high-risk clones. The analysis of the P. aeruginosa resistome should permit to design therapeutic strategies and to monitor the efficacy of administered antibiotic treatments. In this review, the main genes and mutations which shape the P. aeruginosa resistome and the epidemic high-risk clones of P. aeruginosa are reviewed.