Resective surgery is possible in patients with temporal lobe epilepsy due to bilateral isolated hippocampal malformation


DERİCİOĞLU N. , OGUZ K. K. , SOYLEMEZOGLU F., Akalan N. , SAYGI S.

CLINICAL NEUROLOGY AND NEUROSURGERY, vol.111, no.6, pp.554-557, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 111 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1016/j.clineuro.2009.03.002
  • Title of Journal : CLINICAL NEUROLOGY AND NEUROSURGERY
  • Page Numbers: pp.554-557

Abstract

Various hippocampal malformations have been described in the context of widespread cortical malformations inpatients with epilepsy. Isolated hippocampal malformations however are very rarely identified on MR imaging studies. Little is known about the epileptogenicity of these malformations and their pathologic appearance. We present a case with severe bilateral hippocampal malformations who underwent right temporal lobectomy due to intractable temporal lobe epilepsy. Postoperative examination of the resected hippocampus revealed abnormal shape of the dentate gyrus and an atypical convolution of the CA1 pyramidal cell-subicular layers. After surgery, the patient has been seizure free. (c) 2009 Elsevier B.V. All rights reserved.