Resective surgery is possible in patients with temporal lobe epilepsy due to bilateral isolated hippocampal malformation

DERİCİOĞLU N., OGUZ K. K., SOYLEMEZOGLU F., Akalan N., SAYGI S.

CLINICAL NEUROLOGY AND NEUROSURGERY, vol.111, no.6, pp.554-557, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 111 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1016/j.clineuro.2009.03.002
  • Journal Name: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.554-557
  • Keywords: Temporal lobe epilepsy, Bilateral hippocampal malformation, Surgery, Pathology, Prognosis, MIGRATION, SCLEROSIS, SEIZURES, ATROPHY
  • Hacettepe University Affiliated: Yes

Abstract

Various hippocampal malformations have been described in the context of widespread cortical malformations inpatients with epilepsy. Isolated hippocampal malformations however are very rarely identified on MR imaging studies. Little is known about the epileptogenicity of these malformations and their pathologic appearance. We present a case with severe bilateral hippocampal malformations who underwent right temporal lobectomy due to intractable temporal lobe epilepsy. Postoperative examination of the resected hippocampus revealed abnormal shape of the dentate gyrus and an atypical convolution of the CA1 pyramidal cell-subicular layers. After surgery, the patient has been seizure free. (c) 2009 Elsevier B.V. All rights reserved.