Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma


Vogelzang N., Rusthoven J., Symanowski J., Denham C., Kaukel E., Ruffie P., ...More

JOURNAL OF CLINICAL ONCOLOGY, vol.21, no.14, pp.2636-2644, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 14
  • Publication Date: 2003
  • Doi Number: 10.1200/jco.2003.11.136
  • Title of Journal : JOURNAL OF CLINICAL ONCOLOGY
  • Page Numbers: pp.2636-2644

Abstract

Purpose : Patients with malignant pleural mesothelioma, a rapidly progressing malignancy with a median survival time of 6 to 9 months, have previously responded poorly to chemotherapy. We conducted a phase III trial to determine whether treatment with pemetrexed and cisplatin results in survival time superior to that achieved with cisplatin alone.