Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma


Vogelzang N., Rusthoven J., Symanowski J., Denham C., Kaukel E., Ruffie P., ...Daha Fazla

JOURNAL OF CLINICAL ONCOLOGY, cilt.21, sa.14, ss.2636-2644, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 21 Konu: 14
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1200/jco.2003.11.136
  • Dergi Adı: JOURNAL OF CLINICAL ONCOLOGY
  • Sayfa Sayıları: ss.2636-2644

Özet

Purpose : Patients with malignant pleural mesothelioma, a rapidly progressing malignancy with a median survival time of 6 to 9 months, have previously responded poorly to chemotherapy. We conducted a phase III trial to determine whether treatment with pemetrexed and cisplatin results in survival time superior to that achieved with cisplatin alone.