Repeated implantation failure: a new potential treatment option


Makrigiannakis A., BenKhalifa M., Vrekoussis T., Mahjub S., Kalantaridou S. N. , GÜRGAN T.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol.45, no.4, pp.380-384, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1111/eci.12417
  • Title of Journal : EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Page Numbers: pp.380-384

Abstract

BackgroundPrevious studies have shown that the intrauterine administration of peripheral blood mononuclear cells (PBMC) may improve pregnancy outcome of women with repeated implantation failure (RIF). We have demonstrated that, during implantation, corticotropin-releasing hormone (CRH) plays a key role in facilitating endometrial decidualization and maternal-foetal immunotolerance. In the present preliminary study, we investigated whether the intrauterine administration of autologous CRH-treated PBMC can improve clinical pregnancy rates of women with RIF.