Repeated implantation failure: a new potential treatment option

Makrigiannakis A., BenKhalifa M., Vrekoussis T., Mahjub S., Kalantaridou S. N., GÜRGAN T.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol.45, no.4, pp.380-384, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1111/eci.12417
  • Journal Name: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.380-384
  • Hacettepe University Affiliated: Yes

Abstract

BackgroundPrevious studies have shown that the intrauterine administration of peripheral blood mononuclear cells (PBMC) may improve pregnancy outcome of women with repeated implantation failure (RIF). We have demonstrated that, during implantation, corticotropin-releasing hormone (CRH) plays a key role in facilitating endometrial decidualization and maternal-foetal immunotolerance. In the present preliminary study, we investigated whether the intrauterine administration of autologous CRH-treated PBMC can improve clinical pregnancy rates of women with RIF.