Repeated implantation failure: a new potential treatment option

Makrigiannakis A., BenKhalifa M., Vrekoussis T., Mahjub S., Kalantaridou S. N., GÜRGAN T.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, cilt.45, sa.4, ss.380-384, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/eci.12417
  • Dergi Adı: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.380-384
  • Hacettepe Üniversitesi Adresli: Evet

Özet

BackgroundPrevious studies have shown that the intrauterine administration of peripheral blood mononuclear cells (PBMC) may improve pregnancy outcome of women with repeated implantation failure (RIF). We have demonstrated that, during implantation, corticotropin-releasing hormone (CRH) plays a key role in facilitating endometrial decidualization and maternal-foetal immunotolerance. In the present preliminary study, we investigated whether the intrauterine administration of autologous CRH-treated PBMC can improve clinical pregnancy rates of women with RIF.