Inhibition characteristics of hypericin on rat small intestine glutathione-S-transferases

TUNA G., KULAKSIZ ERKMEN G. , DALMIZRAK Ö., Dogan A., ÖĞÜŞ İ. H. , Ozer N.

CHEMICO-BIOLOGICAL INTERACTIONS, cilt.188, sa.1, ss.59-65, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 188 Konu: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.cbi.2010.07.007
  • Dergi Adı: CHEMICO-BIOLOGICAL INTERACTIONS
  • Sayfa Sayıları: ss.59-65

Özet

Glutathione-S-transferases constitute a family of enzymes involving in the detoxification of xenobiotics, signalling cascades and serving as ligandins or/and catalyzing the conjugation of various chemicals and drugs. The widely expressed cytosolic GST-pi is a marker protein in various cancers and its increased concentration is linked to drug resistance. GST-pi is autoregulated by S-glutathionylation and it catalyzes the S-glutathionylation of other proteins in response to oxidative or nitrosative stress. S-glutathionylation of GST-pi results in multimer formation and the breakage of ligand binding interactions with c-Jun NH(2)-terminal kinase (JNK). Another widely expressed GST enzyme, GST-alpha is assumed as a marker in hepatocellular damage, is implicated in cancer, asthma, cardiovascular disease and response to chemotherapy.