Inhibition characteristics of hypericin on rat small intestine glutathione-S-transferases
CHEMICO-BIOLOGICAL INTERACTIONS, cilt.188, sa.1, ss.59-65, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 188 Sayı: 1
- Basım Tarihi: 2010
- Doi Numarası: 10.1016/j.cbi.2010.07.007
- Dergi Adı: CHEMICO-BIOLOGICAL INTERACTIONS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.59-65
- Anahtar Kelimeler: St John's Wort, Hypericin, GST-alpha, GST-pi, Rat small intestine, PHOTODYNAMIC THERAPY, JOHNS-WORT, BREAST-CANCER, EXPRESSION, CELLS, PI, CONSTITUENTS, ISOENZYMES, BINDING, KINASE
- Hacettepe Üniversitesi Adresli: Evet
Özet
Glutathione-S-transferases constitute a family of enzymes involving in the detoxification of xenobiotics, signalling cascades and serving as ligandins or/and catalyzing the conjugation of various chemicals and drugs. The widely expressed cytosolic GST-pi is a marker protein in various cancers and its increased concentration is linked to drug resistance. GST-pi is autoregulated by S-glutathionylation and it catalyzes the S-glutathionylation of other proteins in response to oxidative or nitrosative stress. S-glutathionylation of GST-pi results in multimer formation and the breakage of ligand binding interactions with c-Jun NH(2)-terminal kinase (JNK). Another widely expressed GST enzyme, GST-alpha is assumed as a marker in hepatocellular damage, is implicated in cancer, asthma, cardiovascular disease and response to chemotherapy.