Anti-inflammatory effects of oral and intraperitoneal administration of cerium oxide nanoparticles on experimental hepatic ischemia-reperfusion injury


Zengin A., ERİKÇİ A., TELLİ G., GÜMÜŞEL B., KÖSEMEHMETOĞLU K., UÇAR G., ...More

TURKISH JOURNAL OF SURGERY, vol.38, no.3, pp.255-265, 2022 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.47717/turkjsurg.2022.5620
  • Journal Name: TURKISH JOURNAL OF SURGERY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.255-265
  • Keywords: Ischemia reperfusion, cerium oxide nanoparticles (CONPs), mouse, oxidative stress, inflammation, ISCHEMIA/REPERFUSION INJURY, MECHANISMS, SEVOFLURANE, INHIBITION, TISSUE, MODEL
  • Hacettepe University Affiliated: Yes

Abstract

Objective: Hepatic ischemia-reperfusion (IR) injury occurs in liver surgery, resection, and transplantation. Reactive oxygen species (ROS) produced following IR starts the cascade of cell damage, necrosis/apoptosis, and proinflammatory responses by activating intracellular signaling cascade to drive hepatocellular damage. Cerium oxide nanoparticles (CONPs) act as anti-inflammatory and antioxidant agents. Thus, we evaluated the protective effects of oral (o.g.) and intraperitoneal (i.p.) administration of CONPs on hepatic IR injury.