Transcranial sonography in Perry syndrome

SAKA TOPÇUOĞLU E., TOPÇUOĞLU M. A., Demir A. U., ELİBOL B.

PARKINSONISM & RELATED DISORDERS, cilt.16, sa.1, ss.68-70, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.parkreldis.2009.05.010
  • Dergi Adı: PARKINSONISM & RELATED DISORDERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.68-70
  • Anahtar Kelimeler: Transcranial sonography, Perry syndrome, Substantia nigra, Midbrain raphe, Parkinsonism, PARKINSONS-DISEASE, DEPRESSION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

We report transcranial sonography findings in two siblings (one male and one female) of a proband with Perry syndrome. A moderate degree of parkinsonism and prominent apathy were present in both subjects. The female patient displayed dyspnea and weight loss, indicating more advanced stages of Perry syndrome and for whom recently discovered specific mutation of Perry syndrome had been identified. In both patients. transcranial sonography exhibited marked substantia nigra (SN) hyperechogenicity, which is characteristic of idiopathic Parkinson's disease. This observation, together with similar findings reported for several different types of monogenic forms of parkinsonism, supports the Suggestions that SN hyperechogenicity may be a common sign of nigral degeneration irrespective of underlying molecular pathology. (C) 2009 Elsevier Ltd. All rights reserved.