Drug-associated hepatotoxicity new advances in pathogenesis and clinical findings İlaca baǧli hepatotoksisite

Eren M., SALTIK TEMİZEL İ. N., Koçak N.

Cocuk Sagligi ve Hastaliklari Dergisi, cilt.47, sa.3, ss.222-227, 2004 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 47 Sayı: 3
  • Basım Tarihi: 2004
  • Dergi Adı: Cocuk Sagligi ve Hastaliklari Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.222-227
  • Anahtar Kelimeler: Acetaminophen, Cytochrome P-450, Drug reaction, Hepatotoxicity, Isoniazid
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Drug-induced hepatic injury is often an unrecognized entity, it is the most frequent reason cited for the withdrawal from the market of an approved drug. The liver is essential for the metabolism of drugs and various agents. Most drugs are lipophilic, enabling them to cross the membranes of intestinal cells. They gain a hydrophilic structure through steps of biotransformation by cytochrome P-450 enzyme system in the liver. This process yields water soluble products and these are easily secreted in the urine or bile. Being the center of biotransformation, the liver is also the target organ for drug toxicity. Due to genetic polymorphism of the enzyme system, age, gender differences, infections, coexisting liver pathology and coadministered agents, different individuals exhibit different reactions to the same drug even in the same pharmacological doses. Here we review the type of drug reactions, their clinical outcomes, diagnostic and therapeutic modalities and pathogenesis of drug-induced liver injury.