Omega-3 fatty acid nanocarriers: Characterization and potential applications

Yaghmur A., Ghayas S., Jan H., KALAYCIOĞLU G. D., Moghimi S. M.

Current Opinion in Colloid and Interface Science, vol.67, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Review
  • Volume: 67
  • Publication Date: 2023
  • Doi Number: 10.1016/j.cocis.2023.101728
  • Journal Name: Current Opinion in Colloid and Interface Science
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Cubosomes, Hexosomes, Inverse non-lamellar lyotropic liquid crystalline phases, Omega-3 fatty acid monoacylglycerols, Omega-3 fatty acids
  • Hacettepe University Affiliated: Yes


Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and their precursors ω-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of ω-3 PUFAs, or from single ω-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.