Mechanisms, challenges and opportunities in stroke


Lo E., Dalkara T., Moskowitz M.

NATURE REVIEWS NEUROSCIENCE, cilt.4, sa.5, ss.399-415, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 4 Konu: 5
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1038/nrn1106
  • Dergi Adı: NATURE REVIEWS NEUROSCIENCE
  • Sayfa Sayıları: ss.399-415

Özet

Over the past two decades, research has heavily emphasized basic mechanisms that irreversibly damage brain cells after stroke. Much attention has focused on what makes neurons die easily and what strategies render neurons resistant to ischaemic injury. In the past few years, clinical experience with clot-lysing drugs has confirmed expectations that early reperfusion improves clinical outcome. With recent research emphasizing ways to reduce tissue damage by both vascular and cell-based mechanisms, the spotlight is now shifting towards the study of how blood vessels and brain cells communicate with each other. This new research focus addresses an important need in stroke research, and provides challenges and opportunities that can be used to therapeutic advantage.